Pharmaceutical Analysis MCQ for Nepal Pharmacy Council Exam|Bachelor in Pharmacy Exam
51. The gas used in FID is
a. Helium b. Hydrogen
c. Nitrogen d. Oxygen52. Remove one solvent to get an increasing order of polarity
a. Cyclohexane b. Benzene
c. Hexane d. Chloroform
53. Which one of the following is strong adsorbent used in Column chromatography
a. Sucrose b. Starch
c. Talc d. Charcoal
54. The pressure at which the carrier gas passes into the flow controller/pressure regulator
is between
a. 40 – 80 psi b. 40 – 50 psi
c. 40 – 60 psi d. 40 – 20 psi
55. Temperature control in gas chromatography is important because
a. It affects boiling point of Compounds b. It affects partition coefficient
56. Preheaters are used in Gas chromatography
b. to convert the sample into liquid form so that it mixes with stationary phase liquid
c. to improve separation efficiency
d. to control temperature
57. In a gas chromatographic device, sampling valves are used to introduce
a. Solid b. Liquids
c. Gases d. mixture of Liquids
58. The following is not used as detector in GC
a. Katharometer b. Flame thermocouple detector
c. Bolometer d. Electron capture detector
59. Give an example of a thermal conductivity detector
c. Katharometer d. Flame Ionization detector
60. In a Katharometer, the principle used is
a. Temperature of flame b. Electrical conductivity
c. Thermal conductivity d. Ionization of substances
61. In a thermal conductivity detector, the use of following gas ids ideal
a. Hydrogen or Helium b. Argon
c. Nitrogen d. Methane
62. A carrier gas with low thermal conductivity should not be used in thermal conductivity
detector because the detector sometimes will give
a. Small peaks b. Very large peaks
c. broad peaks d. Negative peaks
63. In flame photometric detector, monitoring of the following is done
a. Temperature of the flame b. Wavelength of the flame
c. Intensity of the flame d. both b & c
64. The Ratio of the distance traveled by center of components to the distance traveled by the solvent front is
a. Rx b. Rf
c. Rm d. Rc
65. In Reverse Phase mode
a. The Stationary phase and mobile phase are polar
b. Stationary phase is non polar and mobile phase is polar
c. Stationary phase is polar and mobile phase is non polar
d. Stationary phase and mobile phase are non polar
66. Which one of the following is strong adsorbent used in thin layer chromatography
a. Sucrose b. Cellulose
c. Alumina d. Starch
68. If the component of the mixture are not completely resolved by a single development,
then which of the following is best suited.
a. Descending Development b. Horizontal Development
c. Multiple Development d. Two dimensional Development
a. Hydrogen or Helium b. Argon
c. Nitrogen d. Methane
62. A carrier gas with low thermal conductivity should not be used in thermal conductivity
detector because the detector sometimes will give
a. Small peaks b. Very large peaks
c. broad peaks d. Negative peaks
63. In flame photometric detector, monitoring of the following is done
a. Temperature of the flame b. Wavelength of the flame
c. Intensity of the flame d. both b & c
64. The Ratio of the distance traveled by center of components to the distance traveled by the solvent front is
a. Rx b. Rf
c. Rm d. Rc
65. In Reverse Phase mode
a. The Stationary phase and mobile phase are polar
b. Stationary phase is non polar and mobile phase is polar
c. Stationary phase is polar and mobile phase is non polar
d. Stationary phase and mobile phase are non polar
66. Which one of the following is strong adsorbent used in thin layer chromatography
a. Sucrose b. Cellulose
c. Alumina d. Starch
68. If the component of the mixture are not completely resolved by a single development,
then which of the following is best suited.
a. Descending Development b. Horizontal Development
c. Multiple Development d. Two dimensional Development
69. In Gas chromatography, the following detector may be used
a. Electron capture detector b. Amperometric detector
c. PDA detector d. UV detector
70. The following visualizing agent is used for detection of alkaloids
a. Ninhydrine b. Dragendroff’s
c. Ferric chloride d. 3, 5-dinitrobenzoic acid
71. Rf value ranges from
a. -1 to 0 b. 0 to 1
c. -1 to -1 d. 0 to 2
72. Ions that will exchange reversibly with other ions in a surrounding solution without any physical change is called as
a. Cation b. Anion
c. Counter ion d. None
73. Cellulose dihydrogen phosphate in paper chromatography is a
a. Ion exchanger b. Complexing agent
c. Adsorbent d. None
74. In TLC the stationary phase used is
a. Adsorbent b. Absorbent
c. Glass plate d. Liquid
75. Cellulose in TLC is used as an adsorbent for the separation of
a. Inorganic ions b. Organic compounds
c. Minerals d. Proteins
76. The most commonly used support material in GLC is
a. Adsorbent b. Diatomaceous earth materials
c. Liquid d. Polymers
77. GLC employs a...........stationary phase and a mobile phase
a. Gas, liquid b. Gas, Solid
b. Liquid, Gas d. Gas adsorbed on solid surface,Liquid
78. Derivatisation of sample solution in GLC is done to
a. Make a polar compound to less polar
b. Reduce peak tailing and improve quantization
c. To increase the volatility of high molecular weight compound
d. All the above
79. All of the following are used as columns in GLC except
a. SCOT b. WCOT
c. Packed columns d. C18 columns
80. The detector which responds to the substances which produce charged ions are
a. Thermal conductivity detectors b. Flame ionization detectors
c. Electron capture detectors d. None
81. Temperature programming is done in GLC to
a. Provide rapid elution of the components
b. Provide high resolution of low boiling compounds
c. Provide rapid elution and optimum resolution of low and high boiling compounds
d. All the above
82. The volume of mobile phase necessary to convey a solute band from point of injection
through the column and to the detector is
a. Elution volume b. Capacity factor
c. Retention volume d. None of the above
83. All of the following is used to measure column efficiency except
a. HETP b. Effective plate number
c. Number of theoretical plates d. Relative retention
84. Height equivalent to a theoretical plate is
a. 16/L (tR/Wb)2 b. L/5.54 (W1/2 / tR)2
c. L/16 (W1/2 / tR)2 d. 5.54 (W1/2 / tR)2
85. The deactivation of silanol group in diatomaceous support material is done by reacting with
a. Dimethyl dichlorosilane b. Dimethyl silane
c. Acetamide d. None
86. The kovats retention index indicate the appearance of a compound in chromatogram with
respect to
a. n alkanes b. Alkenes
c. Alkynes d. Reference standard of same substance
87. Thermionic emission detector is used to analyze compounds with
a. Nitrogen and phosphorus b. Sulphur
c. Carbon d. Inorganic ions
88. Flame photometric detectors are selective for the analysis of
a. Nitrogen and phosphorus b. Sulphur and phosphorus
c. Hydrocarbon d. Inorganic ions
89. The radioactive source used in electron capture detector is
a. Tritium b. Rubidium
c. Radium d. None
90. The choice of gas for Pulsed electron capture detector is
a. Argon mixed with 5 – 10% methane b. Hydrogen
c. Helium d. Nitrogen
91. Derivatization in HPLC is done to extend or enhance
a. Detectability by UV absorption or fluorescence
b. Increase volatility
c. To convert polar substances to less polar substance
d. None
92. Gel permeation or size exclusion chromatography is used when the molecular weight exceeds
a. 1000 daltons b. 1500 daltons
c. 2000 daltons d. 800 daltons
93. The thickness of the adsorbent coated on a porous layer beads in HPLC is
a. 1 – 3 µm b. 2 - 4 µm
c. 4 - 6 µm d. 5 - 6 µm
94. One of the following condition is maintained in programmed temperature GC
a. Temperature of the whole column is raised during analysis
b. Temperature at the sample injection system is raised
c. Temperature at the detector is gradually raised
d. Temperature at the recorder alone is raised
95. The Si – OH in a silanol group is
a. Slightly acidic b. Slightly alkaline
c. Acidic and basic d. Neither acidic nor basic
96. The stationary phase used in gel permeation chromatography is
a. Agarose b. Polyacrylamides
c. Dextran d. All the above
97. Open tubular columns or capillary columns in gas chromatography is first described by
a. Golay b. James and martin
b. Tswett d. Martin and singe
98. Which of the following detector is sensitive for analysis of pesticides and mercaptans
a. Thermal conductivity detector b. Flame ionization detector
c. Flame photometric detector d. Thermionic emission detector
99. Alkali flame ionization detector is also called as
a. Thermal conductivity detector b. Flame ionization detector
c. Flame photometric detector d. Thermionic emission detector
a. Electron capture detector b. Amperometric detector
c. PDA detector d. UV detector
70. The following visualizing agent is used for detection of alkaloids
a. Ninhydrine b. Dragendroff’s
c. Ferric chloride d. 3, 5-dinitrobenzoic acid
71. Rf value ranges from
a. -1 to 0 b. 0 to 1
c. -1 to -1 d. 0 to 2
72. Ions that will exchange reversibly with other ions in a surrounding solution without any physical change is called as
a. Cation b. Anion
c. Counter ion d. None
73. Cellulose dihydrogen phosphate in paper chromatography is a
a. Ion exchanger b. Complexing agent
c. Adsorbent d. None
74. In TLC the stationary phase used is
a. Adsorbent b. Absorbent
c. Glass plate d. Liquid
75. Cellulose in TLC is used as an adsorbent for the separation of
a. Inorganic ions b. Organic compounds
c. Minerals d. Proteins
76. The most commonly used support material in GLC is
a. Adsorbent b. Diatomaceous earth materials
c. Liquid d. Polymers
77. GLC employs a...........stationary phase and a mobile phase
a. Gas, liquid b. Gas, Solid
b. Liquid, Gas d. Gas adsorbed on solid surface,Liquid
78. Derivatisation of sample solution in GLC is done to
a. Make a polar compound to less polar
b. Reduce peak tailing and improve quantization
c. To increase the volatility of high molecular weight compound
d. All the above
79. All of the following are used as columns in GLC except
a. SCOT b. WCOT
c. Packed columns d. C18 columns
80. The detector which responds to the substances which produce charged ions are
a. Thermal conductivity detectors b. Flame ionization detectors
c. Electron capture detectors d. None
81. Temperature programming is done in GLC to
a. Provide rapid elution of the components
b. Provide high resolution of low boiling compounds
c. Provide rapid elution and optimum resolution of low and high boiling compounds
d. All the above
82. The volume of mobile phase necessary to convey a solute band from point of injection
through the column and to the detector is
a. Elution volume b. Capacity factor
c. Retention volume d. None of the above
83. All of the following is used to measure column efficiency except
a. HETP b. Effective plate number
c. Number of theoretical plates d. Relative retention
84. Height equivalent to a theoretical plate is
a. 16/L (tR/Wb)2 b. L/5.54 (W1/2 / tR)2
c. L/16 (W1/2 / tR)2 d. 5.54 (W1/2 / tR)2
85. The deactivation of silanol group in diatomaceous support material is done by reacting with
a. Dimethyl dichlorosilane b. Dimethyl silane
c. Acetamide d. None
86. The kovats retention index indicate the appearance of a compound in chromatogram with
respect to
a. n alkanes b. Alkenes
c. Alkynes d. Reference standard of same substance
87. Thermionic emission detector is used to analyze compounds with
a. Nitrogen and phosphorus b. Sulphur
c. Carbon d. Inorganic ions
88. Flame photometric detectors are selective for the analysis of
a. Nitrogen and phosphorus b. Sulphur and phosphorus
c. Hydrocarbon d. Inorganic ions
89. The radioactive source used in electron capture detector is
a. Tritium b. Rubidium
c. Radium d. None
90. The choice of gas for Pulsed electron capture detector is
a. Argon mixed with 5 – 10% methane b. Hydrogen
c. Helium d. Nitrogen
91. Derivatization in HPLC is done to extend or enhance
a. Detectability by UV absorption or fluorescence
b. Increase volatility
c. To convert polar substances to less polar substance
d. None
92. Gel permeation or size exclusion chromatography is used when the molecular weight exceeds
a. 1000 daltons b. 1500 daltons
c. 2000 daltons d. 800 daltons
93. The thickness of the adsorbent coated on a porous layer beads in HPLC is
a. 1 – 3 µm b. 2 - 4 µm
c. 4 - 6 µm d. 5 - 6 µm
94. One of the following condition is maintained in programmed temperature GC
a. Temperature of the whole column is raised during analysis
b. Temperature at the sample injection system is raised
c. Temperature at the detector is gradually raised
d. Temperature at the recorder alone is raised
95. The Si – OH in a silanol group is
a. Slightly acidic b. Slightly alkaline
c. Acidic and basic d. Neither acidic nor basic
96. The stationary phase used in gel permeation chromatography is
a. Agarose b. Polyacrylamides
c. Dextran d. All the above
97. Open tubular columns or capillary columns in gas chromatography is first described by
a. Golay b. James and martin
b. Tswett d. Martin and singe
98. Which of the following detector is sensitive for analysis of pesticides and mercaptans
a. Thermal conductivity detector b. Flame ionization detector
c. Flame photometric detector d. Thermionic emission detector
99. Alkali flame ionization detector is also called as
a. Thermal conductivity detector b. Flame ionization detector
c. Flame photometric detector d. Thermionic emission detector
100. Deactivation of diatomaceous earth is done by reacting with
a. Trimethyl chlorosilane b. 4- chloroacetanilide
c. Acetic acid d. None
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Comment The Correct Answer |
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Q1. The thickness of the adsorbent layer for TLC is a. 0.5-2mm b.0.1-0.2mm c.0.2-0.25mm d. 1-2mm Q2.
The thickness of the adsorbent in precoated TLC plates ranges
from a. 0.5-2mm b. 0.1-0.2mm c.0.2-0.25mm d. 1-2mm Q3. The retardation factor should not exceed a.1 b.0.1 c. 0.09 d. 2 |
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