Pharmaceutical Analysis Important MCQ for Bachelor in Pharmacy Licenses Examination
1. Thin layer chromatography is also called asa. Flat bed chromatography b. planar chromatography
c. paper chromatography d. Both a & b
2. One of the following is used as a binder in TLC
a. calcium phosphate b. starch
c. both a & b d. cellulose
3. The average particle size of silica gel used in TLC is
a. 15µm b. 60µm
c. 100µm d. 50µm
4. _____________ is used as an inorganic fluorescent indicator
a. silica gel b. Zinc silicate
b. calcium sulphate d. cellulose
5. The thickness of the adsorbent layer for preparative TLC is
a. calcium phosphate b. starch
c. both a & b d. cellulose
3. The average particle size of silica gel used in TLC is
a. 15µm b. 60µm
c. 100µm d. 50µm
4. _____________ is used as an inorganic fluorescent indicator
a. silica gel b. Zinc silicate
b. calcium sulphate d. cellulose
5. The thickness of the adsorbent layer for preparative TLC is
a. 0.5-2mm b. 0.1-0.2mm
c. 0.2-0.25mm d. 1-2mm
6. Chromatography was first invented by
a. Michail tswett b. Egon stahl
c. Ismailov D. Nernst
7. In normal-phase chromatography the stationary phase used is
a. polar b. Non polar
c. Acidic d. none
8. In reverse-phase chromatography the stationary phase used is
a. polar b. Non polar
c. Acidic d. none
9. Among the following, which is used as an adsorbent?
a. Kieselguhr b. Hexane
c. Water d. None
10. One of the following is a weak adsorbent
a. Magnesium oxide b. Activated alumina
c. Activated silica d. Sucrose
11. Which one of the following is a strong adsorbent?
a. Magnesium oxide b. Activated alumina
c. Insulin d. Sucrose
12. The stationary phase used in ion exchange chromatography is
a. Ion Exchange resins b. Adsorbent
c. Molecular gel d. An immiscible liquid
13. The commonly used adsorbent/ adsorbate ratio in column chromatography is
a. 20:1 b. 30:1
b. 50:1 d. a & b
14. The mobile and the stationary phase used in chromatographic techniques are
a. Miscible with each other b. Chemically inert
c. Immiscible with each other d. c & b
15._______chromatographic technique is based on the principle of steric and diffusion effect of the sample
a. Adsorption b. Partition
c. Gel permeation d. Ion exchange
16. The particle size of the stationary phase used in column chromatography is
a. 800 – 900 µ b. 500 - 600 µ
c. 60 - 80µ d. 60 - 200µ
17. Which one of the following statements is correct in the case of column chromatography?
a. The compound with less affinity towards the stationary phase is eluted first
b. The compound with more affinity towards the stationary phase is eluted first
c. The compound with greater affinity towards the mobile phase is eluted first
d. Both a & c
18. The ratio of movement of a component is given by
a. R = Rate of movement of a component/ Rate of movement of mobile phase
b. R = Rate of movement of a mobile phase/ Rate of movement of the component
c. Both a & b
d. None
19. One of the following is an example of medium adsorbing stationary phase
a. Insulin b. Activated magnesia
c. Magnesium carbonate d. Charcoal
20 ..........chromatographic separations are based on the differences in partition characteristics of the individual components
a. Adsorption b. Partition
c. Ion exchange d. Gel permeation
21. One of the following solvents has the least eluting power
a. Petroleum ether b. Acids
c. Water d. Chlorofom
c. 0.2-0.25mm d. 1-2mm
6. Chromatography was first invented by
a. Michail tswett b. Egon stahl
c. Ismailov D. Nernst
7. In normal-phase chromatography the stationary phase used is
a. polar b. Non polar
c. Acidic d. none
8. In reverse-phase chromatography the stationary phase used is
a. polar b. Non polar
c. Acidic d. none
9. Among the following, which is used as an adsorbent?
a. Kieselguhr b. Hexane
c. Water d. None
10. One of the following is a weak adsorbent
a. Magnesium oxide b. Activated alumina
c. Activated silica d. Sucrose
11. Which one of the following is a strong adsorbent?
a. Magnesium oxide b. Activated alumina
c. Insulin d. Sucrose
12. The stationary phase used in ion exchange chromatography is
a. Ion Exchange resins b. Adsorbent
c. Molecular gel d. An immiscible liquid
13. The commonly used adsorbent/ adsorbate ratio in column chromatography is
a. 20:1 b. 30:1
b. 50:1 d. a & b
14. The mobile and the stationary phase used in chromatographic techniques are
a. Miscible with each other b. Chemically inert
c. Immiscible with each other d. c & b
15._______chromatographic technique is based on the principle of steric and diffusion effect of the sample
a. Adsorption b. Partition
c. Gel permeation d. Ion exchange
16. The particle size of the stationary phase used in column chromatography is
a. 800 – 900 µ b. 500 - 600 µ
c. 60 - 80µ d. 60 - 200µ
17. Which one of the following statements is correct in the case of column chromatography?
a. The compound with less affinity towards the stationary phase is eluted first
b. The compound with more affinity towards the stationary phase is eluted first
c. The compound with greater affinity towards the mobile phase is eluted first
d. Both a & c
18. The ratio of movement of a component is given by
a. R = Rate of movement of a component/ Rate of movement of mobile phase
b. R = Rate of movement of a mobile phase/ Rate of movement of the component
c. Both a & b
d. None
19. One of the following is an example of medium adsorbing stationary phase
a. Insulin b. Activated magnesia
c. Magnesium carbonate d. Charcoal
20 ..........chromatographic separations are based on the differences in partition characteristics of the individual components
a. Adsorption b. Partition
c. Ion exchange d. Gel permeation
21. One of the following solvents has the least eluting power
a. Petroleum ether b. Acids
c. Water d. Chlorofom
22. Paper chromatography works on the principle of
a. Adsorption b. Partition
c. Ion exchange d. Gel permeation
23. The technique in which the individual components of a mixture are separated by eluting the column with fresh solvent is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
24. The technique in which the solution of a mixture is percolated continuously through the
column is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
25. The technique in which a solution of a substance, displaces all the components of the
separating mixture is added is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
26. The most reactive group in silica is
a. Si – OH b. Si
c. Si – COOH d. None
27. Which of the following is not used as a binder in the preparation of TLC plates
a. Gypsum b. Starch
c. Both a & b d. Cellulose
28. TLC with unactivated cellulose as a stationary phase follows .......... mechanism of separation b. Partition
a. Adsorption b. Partition
c. Ion exchange d. Gel permeation
23. The technique in which the individual components of a mixture are separated by eluting the column with fresh solvent is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
24. The technique in which the solution of a mixture is percolated continuously through the
column is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
25. The technique in which a solution of a substance, displaces all the components of the
separating mixture is added is
a. Frontal analysis b. Elution analysis
c. displacement analysis d. None
26. The most reactive group in silica is
a. Si – OH b. Si
c. Si – COOH d. None
27. Which of the following is not used as a binder in the preparation of TLC plates
a. Gypsum b. Starch
c. Both a & b d. Cellulose
28. TLC with unactivated cellulose as a stationary phase follows .......... mechanism of separation b. Partition
c. Ion exchange d. Gel permeation
29. Microscopic slides for performing TLC are conveniently coated by
a. Spreading b. spraying
c. Dipping d. None of the above
30. Saturation of the TLC chamber usually eliminates
a. Edge effect b. spreading effect
c. Spotting effect d. Dirt effect
31. One of the following is an example of a non-specific spray reagent in TLC detection
a. Ninhydrin reagent b. Sodium isobismuthate in sulphuric acid
c. Iodine d. dragendorffs reagent
32. Alkaloids can be easily detected by spraying
a. Ninhydrin reagent b. Sodium isobismuthate in sulphuric acid
c. Iodine d. Dragendorffs reagent
33. The thickness of the adsorbent layer for TLC is
29. Microscopic slides for performing TLC are conveniently coated by
a. Spreading b. spraying
c. Dipping d. None of the above
30. Saturation of the TLC chamber usually eliminates
a. Edge effect b. spreading effect
c. Spotting effect d. Dirt effect
31. One of the following is an example of a non-specific spray reagent in TLC detection
a. Ninhydrin reagent b. Sodium isobismuthate in sulphuric acid
c. Iodine d. dragendorffs reagent
32. Alkaloids can be easily detected by spraying
a. Ninhydrin reagent b. Sodium isobismuthate in sulphuric acid
c. Iodine d. Dragendorffs reagent
33. The thickness of the adsorbent layer for TLC is
a. 0.5-2mm b. 0.1-0.2mm
c.0.2-0.25mm d. 1-2mm
34. The thickness of the adsorbent in precoated TLC plates ranges from
a. 0.5-2mm b. 0.1-0.2mm
c.0.2-0.25mm d. 1-2mm
35. The retardation factor should not exceed
a. 1 b. 0.1
c. 0.09 d. 2
36. ....................is used as a stationary phase for the separation of carbohydrates
a. Cellulose b. Kieselguhr
c. Alumina d. Silica gel
37. Activation of a TLC plate is usually done to remove
a. Moisture b. Volatile contaminants
c. Both a & b d. None
38. An adsorbent layer coated with Silicone oil usually follows Separation by
a. Normal phase b. Reverse Phase
c. Adsorption d. Ion exchange
39. In HPTLC the particle size of the adsorbent layer ranges from
c.0.2-0.25mm d. 1-2mm
34. The thickness of the adsorbent in precoated TLC plates ranges from
a. 0.5-2mm b. 0.1-0.2mm
c.0.2-0.25mm d. 1-2mm
35. The retardation factor should not exceed
a. 1 b. 0.1
c. 0.09 d. 2
36. ....................is used as a stationary phase for the separation of carbohydrates
a. Cellulose b. Kieselguhr
c. Alumina d. Silica gel
37. Activation of a TLC plate is usually done to remove
a. Moisture b. Volatile contaminants
c. Both a & b d. None
38. An adsorbent layer coated with Silicone oil usually follows Separation by
a. Normal phase b. Reverse Phase
c. Adsorption d. Ion exchange
39. In HPTLC the particle size of the adsorbent layer ranges from
a. 40 - 50µm b. 4 - 6µm
b. 10 - 12µm d. 20 - 40µm
40. Rx value is
a. Distance traveled by substance/ distance traveled by standard
b. Distance traveled by standard/ Distance traveled by substance
c. Distance traveled by solvent front/ Distance traveled by substance
d. Distance traveled by substance / Distance traveled by the solvent front
41. 3, 5 Dinitro benzoic acid is used for the identification of
a. Cardiac glycosides b. Alkaloids
c. Proteins d. None
42. A saturated solution of 2, 4 – Dinitro phenyl hydrazine is used in the identification of
a. Cardiac glycosides b. Alkaloids
c. Proteins d. Aldehydes and ketones
43. Amino acids are detected by using
a. Dragendorffs reagent b. Ninhydrin reagent
c. Vanillin sulphuric acid d. None
44. Recovery of components of mixtures from the TLC plates are conveniently removed by
a. Craig’s tube b. Glass rod
c. Vacuum d. None
45. TLC in its present form was developed by
a. Michail teswett b. Egon stahl
c. Consden d. None
46. Which among the following compounds is sensitive to detection by FID in Gas Chromatography?
a. Carbon Monoxide b. Sulphur dioxide
c. Water d. Cyclohexane
47. Which among the following is a popular stationary phase in GLC
a. Silica gel b. Kieselguhr
c. Phenyl Silicone d. Dichloromethylene
48. Which among the following ion-exchange resin is ideally used for the exchange of a cation, independent of the pH of the medium?
a. Phenolic ion – Cation exchange resin
b. Carboxyl ion – Cation exchange resin
c. Sulphonic acid – Cation exchange resin
d. Quaternary – Ion exchange resin
49. Which one of the following detectors is not used in Gas Chromatography?
a. Flame Ionization b. Electron multiplier
c. Electron capture d. Thermal conductivity
50. If So3H functional group is present, then the ion exchange resin is
b. 10 - 12µm d. 20 - 40µm
40. Rx value is
a. Distance traveled by substance/ distance traveled by standard
b. Distance traveled by standard/ Distance traveled by substance
c. Distance traveled by solvent front/ Distance traveled by substance
d. Distance traveled by substance / Distance traveled by the solvent front
41. 3, 5 Dinitro benzoic acid is used for the identification of
a. Cardiac glycosides b. Alkaloids
c. Proteins d. None
42. A saturated solution of 2, 4 – Dinitro phenyl hydrazine is used in the identification of
a. Cardiac glycosides b. Alkaloids
c. Proteins d. Aldehydes and ketones
43. Amino acids are detected by using
a. Dragendorffs reagent b. Ninhydrin reagent
c. Vanillin sulphuric acid d. None
44. Recovery of components of mixtures from the TLC plates are conveniently removed by
a. Craig’s tube b. Glass rod
c. Vacuum d. None
45. TLC in its present form was developed by
a. Michail teswett b. Egon stahl
c. Consden d. None
46. Which among the following compounds is sensitive to detection by FID in Gas Chromatography?
a. Carbon Monoxide b. Sulphur dioxide
c. Water d. Cyclohexane
47. Which among the following is a popular stationary phase in GLC
a. Silica gel b. Kieselguhr
c. Phenyl Silicone d. Dichloromethylene
48. Which among the following ion-exchange resin is ideally used for the exchange of a cation, independent of the pH of the medium?
a. Phenolic ion – Cation exchange resin
b. Carboxyl ion – Cation exchange resin
c. Sulphonic acid – Cation exchange resin
d. Quaternary – Ion exchange resin
49. Which one of the following detectors is not used in Gas Chromatography?
a. Flame Ionization b. Electron multiplier
c. Electron capture d. Thermal conductivity
50. If So3H functional group is present, then the ion exchange resin is
a.Strong cation exchange resin
b. Weak cation exchange resin
b.Strong anion exchange resin d. Weak anion exchange resin
b.Strong anion exchange resin d. Weak anion exchange resin
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